Publication

2024

• Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Limin Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang. 2024. Unleashing bioproduction potential of porphyrins by integrating phototrophs-derived cell factory with enzymatic catalysis. Nat Biotechnol. （In press）
• Peipei Zhao, Shengling Cao, Jiahui Wang, Jiaying Lin, Yunzeng Zhang, Chengwei Liu, Hairong Liu, Qingqing Zhang, Mengmeng Wang, Yiwei Meng, Xin Yin, Jun Qi, Lixin Zhang, Xuekui Xia. 2024. Activation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase. Biotechnology & Applied Microbiology. 108(1). https://doi.org/10.1007/s00253-024-13173-8
• Danni Wang, Chenxi Yu, Jie Feng, Liujing Wei, Jun Chen, Zhijie Liu, Liming Ouyang, Lixin Zhang, Feng Liu, Qiang Hua. 2024. Comparative transcriptome analysis reveals the redirection of metabolic flux from cell growth to astaxanthin biosynthesis in Yarrowia lipolytica. Yeast. 0749-503X. https://doi.org/10.1002/yea.3938
• Qingzhou Meng, Xinzhu Wang, Huanqin Dai#, Israa Assani, Mengting Zhang, Peipei Zhao, Longfen Li, Xinyin, Jun Qi, Yang Pan, Lixin Zhang, Xuekui Xia. 2024. A gene cluster encoding a nonribosomal peptide synthetase-like enzyme catalyzes γ-aromatic butenolides. Journal of Asian Natural Products Research. 26(6), 681-689. https://doi.org/10.1080/10286020.2024.2311150
• Chunlei Li, Ziyi Zhou, Weitao Wang, Yanqiu Zhao, Xin Yin, Yiwei Meng, Peipei Zhao, Mengmeng Wang, Xueting Liu, Xinye Wang, Shenlin Wang, Biao Ren, Lixin Zhang, and Xuekui Xia. 2024. Development of Antibacterial Peptides with Membrane Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry. 67(2),1044-1060. https://doi.org/10.1080/10286020.2024.2311150
• Shiwen Qiu, Bowen Yang, Zilong Li, Shanshan Li, Hao Yan, Zhenguo Xin, Jingfang Liu, Xuejin Zhao, Lixin Zhang, Wensheng Xiang, Weishan Wang. 2024. Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts. Metabolic Engineering. 1096-7176. https://doi.org/10.1021/acs.jmedchem.3c01360
• Kangjie Lv, Xinye Wang, Xiaoying Li, Cuiping Xing, Keying Lan, Guoliang Zhu, Songwei Li, Tom Hsiang, Lixin Zhang, Lan Jiang, Xueting Liu, 2024. Combining Feature-Based Molecular Networking and Small-Scale Fermentation to Identify a Bfts-Related Fusoxyordienoid Gene Cluster from Fusarium Oxysporum. Synth Syst Biotechnol. (Accepted)
• Huangong Li, Ling Yu, Zheng Zhu, Dongqi Wu, Yongyuan Ju, Dan Li, Jingyu Zhang, Guoliang Zhu, Lixin Zhang, Yonggui Robin Chi, Yongtao Xie. 2024. Enzyme-Mediated Cross-Benzoin Reaction of Highly Enolizable Aldehydes and Aryl Aldehydes for Acess to Chiral Phosphonates.ChemRxiv. (preprint)
• Xinzhu Wang, Qingzhou Meng, Haiyan Chen, Xin Yin, Huanqin Dai, Peipei Zhao, Yang Pan, Xuekui Xia, Lixin Zhang. 2024. Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects. Natural Product Research, 38(8), 1311–1319. https://doi.org/10.1080/14786419.2022.2140150
• Zhanren Cong, Qiang Yin, Kunhong Tian, Njeru Joe Mukoma, Liming Ouyang, Tom Hsiang, Lixin Zhang, Lan Jiang, and Xueting Liu. 2024. Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases. J. Fungi. 10(5), 350. https://doi.org/10.3390/jof10050350
• Jiaming Yu, Yue Zhang, Li Zhang, Jie Shi, Kun Wang, Weize Yuan, Zexu Lin, Shangqian Ning, Bohao Wang, Xinye Wang, Yuyang Qiu, Tom Hsiang, Lixin Zhang, Xueting Liu, Guoliang Zhu. 2024. New N-acylated aminoalkanoic acids from tea roots derived biocontrol agent Clonostachys rosea 15020. Synth Syst Biotechnol. 9(2): 684–693. https://doi.org/10.1016/j.synbio.2024.05.006
• Xinye Wang, Yiyi Huang, Weiyan Zhang, Kangjie Lv, Xiaoying Li, Zhixin Wang, Li Zhang, Tom Hsiang, Lixin Zhang, Liming Ouyang, Xueting Liu. 2024. Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket. Synth Syst Biotechnol. 9(2):380–387. https://doi.org/10.1016/j.synbio.2024.03.007
• Zhiheng Yang, Bixiao Li, Ruihong Bu, Zhengduo Wang, Zhenguo Xin, Zilong Li, Lixin Zhang, Weishan Wang. 2024. A highly efficient method for genomic deletion across diverse lengths in thermophilic Parageobacillus thermoglucosidasius. Synth Syst Biotechnol. 9(2):658–666. https://doi.org/10.1016/j.synbio.2024.05.009

2023

• Yuting Shuai, Anan Xu, Jiayi Li, Zhaoxi Han, Dini Ma, Hairong Duan, Xinye Wang, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Yi-Lei Zhao, Yaojun Tong, Shenlin Wang, Xinyi He, Zixin Deng, Guang Liu, Lixin Zhang. 2023. Profile and relaxation of sequence-specificity of DNA sulfur binding domains facilitate new nucleic acid detection platform. Science Bulletin, 2095-9273. https://doi.org/10.1016/j.scib.2023.07.012
• Lixin Zhang, Xueting Liu, Xinye Wang, Guoliang Zhu, Heng Song, Ronghai Cheng, Nathchar Naowarojna, Catherine E. Costello, Pinghua Liu. 2023. Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1”. Angew. Chem. Int. Ed. e202218643. https://doi.org/10.1002/anie.202218643
• Zhiheng Yang, Zilong Li, Bixiao Li, Ruihong Bu, Gaoyi Tan, Zhengduo Wang, Hao Yan, Zhenguo Xin, Guojian Zhang, Ming Li, Hua Xiang, Lixin Zhang, Weishan Wang. 2023. A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering. Nat Commun. 14, 6193. https://doi.org/10.1038/s41467-023-41973-5
• Li, Chunlei ; Zhou, Ziyi; Wang, Weitao; Zhao, Yanqiu; Yin, Xin; Meng, Yiwei; Zhao, Peipei; Wang, Mengmeng; Liu, Xueting; Wang, Xinye; Wang, Shenlin; Ren, Biao; Lixin Zhang, Xuekui Xia. “Development of Antibacterial Peptides with Membrane-Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus” Journal of Medicinal Chemistry. (Accepted)
• 王凯，张婉，黄云海，张立新，娄春波.噬菌体疗法在胞内病原菌治疗中的挑战与思考.2023.合成生物学.1-14. https://doi.org/10.12211/2096-8280.2023-002
• Mengzhen Jiang, Man Liu, Guodi Liu, Jiawen Ma, Lixin Zhang, Shenlin Wang. 2023. Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1. mAbs, 15:1. https://doi.org/10.1080/19420862.2023.2236740
• Xi Ying, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia. 2023. Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model. Biogerontology. 1573-6768. https://doi.org/10.1007/s10522-023-10058-7
• Mengmeng Wang, Kunyu Qu, Peipei Zhao, Xin Yin, Yiwei Meng, Piet Herdewijin, Chao Liu, Lixin Zhang, Xuekui Xia. 2023. Synthesis and anticancer evaluation of acetylated-lysine conjugated gemcitabine prodrugs. RSC Med. Chem., 2023, 14, 1572-1580. https://doi.org/10.1039/D3MD00190C
• Zhaojuan Zheng, Xia Wang, Liming Ouyang, Wenxia Chen, Lixin Zhang, and Yulin Cao. 2023. Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H2O2-Induced Senescence. Antioxidants. 12(7), 1334. https://doi.org/10.3390/antiox12071334
• Yaojun Tong, Lixin Zhang. 2023. Discovering the next decade’s synthetic biology research trends with ChatGPT. Synth Syst Biotechnol. 8(2):220-223. https://doi.org/10.1016/j.synbio.2023.02.004
• Tao Zhang, Jianjv Feng, Wenni He, Xiaoting Rong, Hui Lv, Jun Li, Xinxin Li, Hao Wang, Lu Wang, Lixin Zhang, Liyan Yu 2023. Genomic and Transcriptomic Approaches Provide a Predictive Framework for Sesquiterpenes Biosynthesis in Desarmillaria tabescens CPCC 401429. J. Fungi 2023, 9(4), 481. https://doi.org/10.3390/jof9040481
• Xiaoqian Zeng, Shuliu Wang, Mindong Liang, Weishan Wang, Yue Jiang, Fei Xu, Leshi Liu, Hao Yan, Yaojun Tong, Lixin Zhang, Gao-Yi Tan. 2023. An in vitro CRISPR-Cas12a-mediated protocol for direct cloning of large DNA fragments. STAR Protocols. 4,102435. https://doi.org/10.1016/j.xpro.2023.102435
• Yuting Shuai, Yi Ju, Yuanhang Li, Dini Ma, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Shenlin Wang, Lixin Zhang, Guang Liu. 2023. A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain. Synth Syst Biotechnol. 8(2), 213-219. https://doi.org/10.1016/j.synbio.2023.02.002
• Meijun Shi, Mingfu Gao, Hao Sun, Weichao Yang, Hongxia Zhao, Lixin Zhang, and Hui Xu. 2023. Exogenous 2-keto-L-gulonic Acid Supplementation as a Novel Approach to Enhancing L-ascorbic Acid Biosynthesis in Zebrafish. Animals. 15:2502. https://doi.org/10.3390/ani13152502
• Haishuo Ji, Lei Wan, Yanxin Gao, Ping Du, Wenjin Li, Hang Luo, Jiarui Ning, Yingying Zhao, Huangwei Wang, Lixin Zhang, Liyun Zhang. 2023. Hydrogenase as the basis for green hydrogen production and utilization. JEC. 85, 348-362. https://doi.org/10.1016/j.jechem.2023.06.018
• Jiaming Yu, Dongyuan Lv, Lixin Zhang. 2023. De novo biosynthesis of a vinblastine precursor in Pichia pastoris. Synth Syst Biotechnol. 8(2): 300-301. https://doi.org/10.1016/j.synbio.2023.04.001
• Xinye Wang, Sha Hu, Jun Wang, Tao Zhang, Ke Ye, Ai Wen, Guoliang Zhu, Arturo Vegas, Lixin Zhang, Wupeng Yan, Xueting Liu, Pinghua Liu. 2023. Biochemical and structural characterization of OvoA_Th2: a mono-nuclear non-heme iron enzyme from Hydrogenimonas thermophila for ovothiol biosynthesis. ACS Catalysis. cs-2023-04026f.R2. https://doi.org/10.1021/acscatal.3c04026
• Wenyue Hu, Bingxu Yang, Qingjie Xiao, Yuli Wang, Yuting Shuai, Gong Zhao, Lixin Zhang, Zixin Deng, Xinyi He, Guang Liu, Characterization of a promiscuous DNA sulfur binding domain and application in site-directed RNA base editing. 2023. Nucleic Acids Research. 10782–10794. https://doi.org/10.1093/nar/gkad743
• Lan Jiang, Tianji Zhang, Hongzhong Lu, Saijuan Li, Kangjie Lv, Alex Tuffour, Lixin Zhang, Kan Ding, Jin-Ping Li, Hongmei Li, Xueting Liu. 2023. Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing. Synth Syst Biotechnol. 8(1): 11-19. https://doi.org/10.1016/j.synbio.2022.10.002
• Xia Wang, Liming Ouyang, Wenxia Chen, Yulin Cao, Lixin Zhang, Efficient expansion and delayed senescence of hUC-MSCs by microcarrier–bioreactor system. 2023. Stem Cell Res Ther .14, 284. https://doi.org/10.1186/s13287-023-03514-1

2022

• Guoliang Zhu, Wupeng Yan, Xinye Wang, Ronghai Cheng, Nathchar Naowarojna, Kun Wang, Jun Wang, Heng Song, Yuyang Wang, Hairong Liu, Xuekui Xia, Catherine E. Costello, Xueting Liu, Lixin Zhang, Pinghua Liu. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au 2022, 2, 7, 1686–1698. https://doi.org/10.1021/jacsau.2c00248
• Mindong Liang, Leshi Liu, Fei Xu, Xiaoqian Zeng, Ruijun Wang, Jinling Yang, Weishan Wang, Loganathan Karthik, Jiakun Liu, Zhiheng Yang, Guoliang Zhu, Shuliu Wang, Linquan Bai, Yaojun Tong, Xueting Liu, Min Wu, Lixin Zhang, Gao-Yi Tan. 2022. Activating cryptic biosynthetic gene cluster through a CRISPR–Cas12a-mediated direct cloning approach. Nucleic Acids Research, 50(6): 3581-3592. https://doi.org/10.1093/nar/gkac181
• Zhao, Sha; Li, Xinming; Wen, Ziyang; Zou, Mengbing; Yu, Ge; Liu, Xiangyang; Mao, Jiafei; Lixin Zhang; Xue, Yi; Fu, Riqiang; Wang, Shenlin. 2022. Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy. IScience, 25(11): 105322. https://doi.org/10.1016/j.isci.2022.105322
• Cheng, Ronghai; Weitz, Andrew C.; Paris, Jared; Tang, Yijie; Zhang, Jingyu; Song, Heng; Naowarojna, Nathchar; Li, Kelin; Qiao, Lu; Lopez, Juan; Grinstaff, Mark W.; Lixin Zhang; Guo, Yisong; Elliott, Sean; Liu, Pinghua. 2022. OvoA_Mtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities. Chemical Science, 13(12): 3589-3598. https://doi.org/10.1039/D1SC05479A
• Jiang, Lan; Lv, Kangjie; Zhu, Guoliang;Lin, Zhi; Zhang, Xue; Xing, Cuiping; Yang, Huanting; Zhang, Weiyan; Wang, Zhixin; Liu, Chengwei; Qu, Xudong; Hsiang, Tom; Lixin Zhang; Liu, Xueting. 2022. Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae. Synthetic and Systems Biotechnology, 7(4): 1142-1147. https://doi.org/10.1016/j.synbio.2022.08.002
• Jiang, Lan; Yang, Huanting; Zhang, Xue; Li, Xiaoying; Lv, Kangjie; Zhang, Weiyan; Zhu, Guoliang; Liu, Chengwei; Wang, Yongheng; Hsiang, Tom; Lixin Zhang,; Liu, Xueting. 2022. Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach. Applied microbiology and biotechnology, 106(18): 6047-6057. https://doi.org/10.1007/s00253-022-12125-4
• Lu, Wanying; Zhu, Guoliang; Yuan, Weize; Han, Zhaoxi; Dai, Huanqin; Mostafa Basiony; Lixin Zhang; Liu Xueting; Hsiang, Tom; Zhang, Jingyu. 2021. Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum. Synthetic and Systems Biotechnology, 446-451. https://doi.org/10.1016/j.synbio.2021.10.001
• Li, Zhenghong; Zhang, Chengyu; Wang, Zhengduo; Yan, Hao; Li, Chuan; Yang, Zhiheng; Li, Zilong; Lixin Zhang; Wang, Weishan. 2022. High-throughput and reliable acquisition of in vivo turnover number fuels precise metabolic engineering. Synthetic and Systems Biotechnology, 7(1): 541-543. https://doi.org/10.1016/j.synbio.2021.12.006
• Wang, Dan-Ni; Feng, Jie; Yu, Chen-Xi; Zhang, Xin-Kai; Chen, Jun; Wei, Liu-Jing; Liu, Zhijie; Ouyang, Liming; Lixin Zhang; Hua, Qiang; Liu, Feng. 2022. Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica. Synthetic and Systems Biotechnology, 7(4): 1133-1141. https://doi.org/10.1016/j.synbio.2022.08.001
• Wang, Xuyuan; Darbandsari, Mersa; Lixin Zhang; Deng, Zixin. 2022. Exploiting synthetic regulatory elements for non-dominant microorganisms. Synthetic and Systems Biotechnology, 7(2): 839-840. https://doi.org/10.1016/j.synbio.2022.03.009
• Wang, Xinzhu; Meng, Qingzhou; Chen, Haiyan; Yin, Xin; Dai, Huanqin; Zhao, Peipei; Pan, Yang; Xia, Xuekui; Lixin Zhang. 2022. Secondary metabolites isolated from Penicillium christenseniae SD. 84 and their antimicrobial resistance effects. Natural Product Research. 6;1-9. https://doi.org/10.1080/14786419.2022.2140150
• Zhao, Peipei; Liu, Hairong; Wu, Qinghua; Meng, Qingzhou; Qu, Kunyu; Yin, Xin; Wang, Mengmeng; Zhao, Xiangxiang; Qi, Jun; Meng, Yiwei; Xia, Xuekui; Lixin Zhang. 2022. Investigation of chetomin as a lead compound and its biosynthetic pathway. Applied microbiology and biotechnology, 106(8): 3093-3102. https://doi.org/10.1007/s00253-022-11925-y
• Jiang, Lan; Zhang, Tianji; Lu, Hongzhong; Li, Saijuan; Lv, Kangjie; Tuffour, Alex; Lixin Zhang; Ding, Kan; Li, Jin-Ping; Li, Hongmei; Liu, Xueting. 2022. Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing. Synthetic and Systems Biotechnology, 8(1): 11-19. https://doi.org/10.1016/j.synbio.2022.10.002
• Han, Jianying; Liu, Xueting; Lixin Zhang; Quinn, Ronald J.; Feng, Yunjiang. 2022. Anti-mycobacterial natural products and mechanisms of action. Natural Product Reports, 39(1): 77-89. https://doi.org/10.1039/d1np00011j
• Wang, Xinye; Wang, Zhixin; Zhu, Guoliang; Jiang, Lan; Zhang, Weiyan; Huang, Yiyi; Cong, Zhanren; Zhao, Yi-Lei; Xu, Jian-He; Hsiang, Tom; Lixin Zhang; Chen, Qi; Liu, Xueting. 2022. Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases. Chemical Communications, 58(68): 9476-9479. https://doi.org/10.1039/d2cc03644d
• Zhang, Donghui; Shi, Chao; Cong, Zihao; Chen, Qi; Bi, Yufang; Zhang, Junyu; Ma, Kaiqian; Liu, Shiqi; Gu, Jiawei; Chen, Minzhang; Lu, Ziyi; Zhang, Haodong; Xie, Jiayang; Xiao, Ximian; Liu, Longqiang; Jiang, Weinan; Shao, Ning; Chen, Sheng; Zhou, Min; Shao, Xiaoyan; Dai, Yidong; Li, Maoquan; Lixin Zhang; Liu, Runhui. 2022. Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity. Advanced Science, 9(14). https://doi.org/10.1002/advs.202104871
• Basiony, Mostafa; Ouyang, Liming; Wang, Danni; Yu, Jiaming; Zhou, Liming; Zhu, Mohan; Wang, Xuyuan; Feng, Jie; Dai, Jing; Shen, Yijie; Zhang, Chengguo; Hua, Qiang; Yang, Xiuliang; Lixin Zhang*. 2022. Optimization of Microbial Cell Factories for Astaxanthin Productio n: Biosynthesis and Regulations, Engineering Strategies and Fermentation Optimization Strategies. Synthetic and Systems Biotechnology, 7(2):16. https://doi.org/10.1016/j.synbio.2022.01.002

2021

• Zhao, Xiangxiang; Wang, Zhengduo; Yang, Bowen; Li, Zilong; Tong, Yaojun; Bi, Yuhai; Li, Zhenghong; Xia, Xuekui; Chen, Xiangyin; Lixin Zhang; Wang, Weishan; Tan, Gao-Yi. 2021. Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection. Synthetic and Systems Biotechnology, 6(4): 283-291. https://doi.org/10.1016/j.synbio.2021.09.007
• Shi, Tong; Zhang, Lu; Liang, Mindong; Wang, Weishan; Wang, Kefeng; Jiang, Yue; Liu, Jing; He, Xinwei; Yang, Zhiheng; Chen, Haihong; Li, Chuan; Lv, Dongyuan; Zhou, Liming; Chen, Biqin; Li, Dan; Lixin Zhang; Tan, Gao-Yi. 2021. Screening and engineering of high- activity promoter elements through transcriptomics and red fluorescent protein visualization in Rhodobacter sphaeroides. Synthetic and Systems Biotechnology, 6(4): 335-342. https://doi.org/10.1016/j.synbio.2021.09.011
• Xiangxiang Zhao, Shanshan Li, Guang Liu, Zhong Wang, Zhiheng Yang, Quanwei Zhang, Mindong Liang, Jiakun Liu, Zilong Li, Yaojun Tong, Guoliang Zhu, Xinye Wang, Lan Jiang, Weishan Wang, Gao-Yi Tan, Lixin Zhang. A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes. Science Bulletin, 2021, 66(1): 69-77. https://doi.org/10.1016/j.scib.2020.09.004
• Yaojun Tong, Jingyu Zhang, Nuo Sun, Xiang-Ming Wang, Qi Wei, Yu Zhang, Ren Huang,Yingying Pu, Huanqin Dai, Biao Ren, Gang Pei, Fuhang Song, Guoliang Zhu, Xinye Wang, Xuekui Xia, Xiangyin Chen, Lan Jiang, Shenlin Wang, Liming Ouyang, Ning Xie, Buchang Zhang, Yuanying Jiang, Xueting Liu, Richard Calderone, Fan Bai, Lixin Zhang, Gil Alterovitz. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin, 2021, 66: 1895–1905. https://doi.org/10.1016/j.scib.2020.12.035
• Zhang Jiong, Zhao Xiangxiang, Cappiello John R, Yang Yi, Cheng Yunfei, Liu Guang, Fang Wenjing, Luo Yinzhu, Zhang Yu, Dong Jiajia, Zhang Lixin, Sharpless K Barry. Identification of simple arylfluorosulfates as potent agents against resistant bacteria. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(28): e2103513118. https://doi.org/10.1073/pnas.2103513118
• Li Shanshan; Yang Bowen; Tan Gao-Yi; Ouyang Li-Ming; Qiu Shiwen; Wang Weishan; Xiang Wensheng; Zhang Lixin. Polyketide pesticides from actinomycetes. Current Opinion in Biotechnology, 2021, 69: 299-307. https://doi.org/10.1016/j.copbio.2021.05.006
• Jingyu Zhang, Lan Jiang, Xiangyin Chen, Kangjie Lv, Mostafa Basiony, Guoliang Zhu, Loganathan Karthik, Liming Ouyang, Lixin Zhang, Xueting Liu. Recent advances in biotechnology for marine enzymes and molecules, Current Opinion in Biotechnology, 2021, 69:308–315. https://doi.org/10.1016/j.copbio.2021.05.009
• Lan Jiang, Guoliang Zhu, Jianying Han, Chengjian Hou, Xue Zhang, Zhixin Wang, Weize Yuan, Kangjie Lv, Zhanren Cong, Xinye Wang, Xiangyin Chen, Loganathan Karthik, Huanting Yang, Xuyuan Wang, Gaoyi Tan, Guang Liu, Liya Zhao, Xuekui Xia, Xiangyang Liu, Shushan Gao, Lei Ma, Mei Liu, Biao Ren, Huanqin Dai, Ronald J. Quinn, Tom Hsiang, Jingyu Zhang, Lixin Zhang, Xueting Liu, Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. Applied Microbiology Biotechnology, 2021, 105 (13): 5407–5417. doi: 10.1007/s00253-021-11192-3. https://doi.org/10.1007/s00253-021-11192-3
• Yaojun Tong, Jingyu Zhang, Luoqiang Wang, Qinqin Wang, Huang Huang, Xiangyin Chen, Qing Zhang, Hantian Li, Nuo Sun, Guang Liu, Buchang Zhang, Fuhang Song, Gil Alterovitz, Huanqin Dai, Lixin Zhang, Hyper-Synergistic Antifungal Activity of Rapamycin and Peptide-Like Compounds against Candida albicans Orthogonally via Tor1 Kinase. ACS infectious diseases, 2021,7(10): 2826-2835. https://doi.org/10.1021/acsinfecdis.1c00448
• Wanying Lu, Guoliang Zhu, Weize Yuan, Zhaoxi Han, Huanqin Dai, Mostafa Basiony, Lixin Zhang, Xueting Liu, Tom Hsiang, Jingyu Zhang. Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum. Synthetic and Systems Biotechnology. 2021, 6(4): 446–451. 30 Nov 2021. https://doi.org/10.1016/j.synbio.2021.10.001
• Zhao Xiangxiang, Wang Zhengduo, Yang Bowen, Li Zilong, Tong Yaojun, Bi Yuhai, Li Zhenghong, Xia Xuekui, Chen Xiangyin, Zhang Lixin, Wang Weishan, Tan Gao-Yi*. Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection. Synthetic and Systems Biotechnology, 2021, 6(4) : 283–291. https://doi.org/10.1016/j.synbio.2021.09.007
• Jiang Lan, Huang Pei, Ren Biao, Song Zhijun, Zhu Guoliang, He Wenni, Zhang Jingyu, Oyeleye Ayokunmi, Dai Huanqin, Zhang Lixin, Liu Xueting. Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128. Applied microbiology and biotechnology, 2021, 105(12): 1–12. https://doi.org/10.1007/s00253-021-11226-w
• Yang Zhiheng, Sun Qingqing, Tan Gaoyi, Zhang Quanwei, Wang Zhengduo, Li Chuan, Qi Fengxian, Wang Weishan, Zhang Lixin, Li Zilong. Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production. Microbial biotechnology, 2021, 14(2): 363–373. https://doi.org/10.1111/1751-7915.13543
• Wu Panpan, Chen Ketao, Li Bowen, Zhang Yanni, Wu Hang, Chen Yuhong, Ren Shaohua, Khan Sabir, Zhang Lixin, Zhang Buchang. Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes. mBio, 2021, e0229821-e0229821. https://doi.org/10.1128/mbio.02298-21
• Han Jianying, Jiang Lan, Zhang Lixin, Quinn Ronald J, Liu Xueting, Feng Yunjiang. Peculiarities of meroterpenoids and their bioproduction. Applied microbiology and biotechnology, 2021, 105(10): 1-17. https://doi.org/10.1007/s00253-021-11312-z
• Zhao Peipei, Yang Meng, Zhu Guoliang, Zhao Bo, Wang Hong, Liu Hairong, Wang Xinzhu, Qi Jun, Yin Xin, Yu Lumin, Meng Yiwei, Li Zhipu, Zhang Lixin, Xia Xuekui. Mollicellins S-U, three new depsidones from Chaetomium brasiliense SD-596 with anti-MRSA activities. The Journal of Antibiotics, 2021, 74(5): 317-323. https://doi.org/10.1038/s41429-020-00398-8

2020

• Weishan Wang, Shanshan Li, Zilong Li, Jingyu Zhang, Keqiang Fan, Gaoyi Tan, Guomin Ai, Sin Man Lam, Guanghou Shui, Zhiheng Yang, Hongzhong Lu, Pinjiao Jin, Yihong Li, Xiangyin Chen, Xuekui Xia, Xueting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang, Siliang Zhang, Gil Alterovitz, Wensheng Xiang and Lixin Zhang. Harnessing cellular triacylglycerol pool for titer improvement of polyketides in Streptomyces. Nat Biotechnol 38, 76–83(2020). https://doi.org/10.1038/s41587-019-0335-4
• Qiushui Wang, Feng Xie, Yaojun Tong, Rebecca Habisch, Bowen Yang, Lixin Zhang, Rolf Müller and Chengzhang Fu. Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes. Appl Microbiol Biotechnol 104, 225–239 (2020). https://doi.org/10.1007/s00253-019-10223-4
• Jingyu Zhang, Bixiao Li, Yujie Qin, Loganathan Karthik, Guoliang Zhu, Chengjian Hou, Lan Jiang, Miaomiao Liu, Xin Ye, Mei Liu, Tom Hsiang, Huanqin Dai, Lixin Zhang and Xueting Liu. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137. Appl Microbiol Biotechnol 104, 1533–1543 (2020). https://doi.org/10.1007/s00253-019-10217-2
• Yurong Xu, Yaqian Tang, Nian Wang, Jing Liu, Xinlu Cai, Hongyi Cai, Jie Li, Guoqing Tan, Ruihua Liu, Linquan Bai, Lixin Zhang, Hang Wu and Buchang Zhang. Transcriptional regulation of a leucine-responsive regulatory protein for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis. Appl Microbiol Biotechnol 104, 2575–2587 (2020). https://doi.org/10.1007/s00253-020-10381-w
• Wei Qiu, Yujie Zhou, Zixin Li, Tu Huang, Yuhan Xiao, Lei Cheng, Xian Peng, Lixin Zhang, Biao Ren. Application of Antibiotics/Antimicrobial Agents on Dental Caries. Biomed Res Int. 2020 Jan 31;2020:5658212. https://doi.org/10.1155/2020/5658212
• Jianying Han, Jingyu Zhang, Zhijun Song, Guoliang Zhu, Miaomiao Liu, Huanqin Dai, Tom Hsiang, Xueting Liu, Lixin Zhang, Ronald J Quinn and Yunjiang Feng. Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Appl Microbiol Biotechnol 104, 3835–3846 (2020). https://doi.org/10.1007/s00253-020-10522-1
• Fan Wu, Jing Zhang, Fuhang Song, Sanshan Wang, Hui Guo, Qi Wei, Huanqin Dai, Xiangyin Chen, Xuekui Xia, Xueting Liu, Lixin Zhang, Jin-Quan Yu and Xiaoguang Lei. Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis. ACS Cent. Sci. 2020, 6, 6, 928–938. https://doi.org/10.1021/acscentsci.0c00122
• Zhixing Cao, Jiaming Yu, Weishan Wang, Hongzhong Lu, Xuekui Xia, Hui Xu, Xiuliang Yang, Lianqun Bao, Qing Zhang, Huifeng Wang, Siliang Zhang and Lixin Zhang. Multi-scale data-driven engineering for biosynthetic titer improvement. Current Opinion in Biotechnology. Curr Opin Biotechnol. 2020 Oct;65:205-212. https://doi.org/10.1016/j.copbio.2020.04.002

2019

• Mindong Liang#, Zilong Li#, Weishan Wang#, Jiakun Liu#, Leshi Liu, Loganathan Karthik, Guoliang Zhu, Kefeng Wang, Yuting Shuai, Jiaming Yu, Lu Zhang, Chuan Li, Qian Zhang, Tong Shi, Liming Zhou, Man Wang, Zhong Wang, Jing Yu, Feng Xie, Huanqin Dai, Xuetin Liu, Jingyu Zhang, Guang Liu, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gil Alterovitz, Gao-Yi Tan*, Zhang LX*. 2019. A CRISPR/Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communications. 10:3672-6
• Xianjun Chen, Dasheng Zhang, Ni Su, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Zhang LX, Yuzheng Zhao, Linyong Zhu, Joseph Loscalzo, Yi Yang. 2019. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Natrue Biotech. 37,1287-1293.
• Zhang, L., Liu, L., Wang, K. F., Xu, L., Zhou, L., Wang, W., Zhang LX, GY Tan*. (2019). Phosphate limitation increases coenzyme Q10 production in industrial Rhodobacter sphaeroides HY01. Synthetic And Systems Biotechnology, 4(4), 212-219.
• Hu, JS; Li, Z; Gao, JY; He, HT; Dai, HQ; Xia, XK; Liu, CH*; Zhang LX*; Song, FH* (2019) New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Mar. Drugs 17(5), 262.
• Zhang, Jingyu,†, Wang, Zhenzhen,†, Song, Zhijun,†, Karthik, Loganathan, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Han, Jianying, Ma, Rong, Li, Li, Zhang Lixin*, Liu, Xueting*, Hsiang, Tom*. 2019. Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049. Synthetic and Systems Biotechnology. 4(4):173-179
• Wu, RJ; Ren, TT; Gao, JY; Wang, L; Yu, QL; Yao, Z; Song, GQ; Ruan, WB; Niu, CW; Song, FH; Zhang, LX*; Li, MC*; Wang, JG* (2019) Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. Eur. J. Med. Chem. 162, 348
• Singh, V*; Singh, K; Nand, A; Dai, HQ; Wang, JG; Zhang, LX; Merino, A; Zhu, JS (2019) Small molecule microarray screening methodology based on surface plasmon resonance imaging. Arab. J. Chem. 12(8)2111.
• Wu H, Chu Z, Zhang W, Zhang C, Ni J, Fang H, Chen Y, Wang Y, Zhang LX*, Zhang B*. 2019. Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea. Journal of Biological Engineering. 13:11-16. https://doi.org/10.1186/s13036-018-0135-2
• Xu Y, Ke M, Li J, Tang Y, Wang N, Tan G, Wang Y, Liu R, Bai L, Zhang LX, Wu H*, Zhang B*. 2019. TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis. Appl Environ Microbiol. 85(1). pii: e02091-18. doi: 10.1128/AEM.02091-18.
• Liu J, Chen Y, Li L, Yang E, Wang Y, Wu H, Zhang LX*, Wang W*, Zhang B*. 2019. Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 46(7):1013-1024
• Wu RJ, Ren T, Gao JY, Wang L, Yu Q, Yao Z, Song GQ, Ruan WB, Niu CW, Song FH, Zhang LX*, Li M*, Wang JG*. 2019. Eur J Med Chem. 162:348-363.
• Han J, Zhang J, Song Z, Liu M, Hu J, Hou C, Zhu G, Jiang L, Xia X, Quinn RJ, Feng Y, Zhang LX*,Hsiang T*, Liu X*. 2019. Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Appl Microbiol Biotechnol.103(13):5167-81.
• Song Z, Gao J, Hu J, He H, Huang P, Zhang LX, Song F. 2019. One new xanthenone from the marine-derived fungus Aspergillus versicolor MF160003. Nat Prod Res. 22:1-6.
• Li B, Wu Y, Zhang W, Zhang S, Shao N, Zhang W, Zhang LX, Fei J, Dai Y, Liu R. 2019. Efficient synthesis of amino acid polymers for protein stabilization. Biomater Sci. doi: 10.1039/c9bm00484j.
• Hu J, Li Z, Gao J, He H, Dai H, Xia X, Liu C, Zhang LX, Song F. 2019. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Mar Drugs. 17(5). pii: E262. doi: 10.3390/md17050262.
• Chunlei Li; Yao Wen; Ying He; Jianhua Zhu; Xin Yin; Jianing Yang; Zhang LX; Liyan Song; Xuekui Xia; Rongmin Yu. 2019. Purification and characterization of a novel β-1,3-glucanase from Arca inflata and its immune-enhancing effects. Food Chemistry, 290: 1-9.
• Qian Deng, Liqiongzi Xiao, Yang Liu, Zhang LX, Zixin Deng, Changming Zhao. 2019. Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Synthetic and Systems Biotechnology 4(1), 34-39.

2018

• Cao, J.#, Yao, Y.#, Fan, K., Tan, G., Xiang, W., Xia, X., Li, S.*, Wang, W.*, and Zhang LX*. 2018. Harnessing a novel capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Sci Adv, (doi: 10.1126/sciadv.aau4602).
• 刘乐诗，谭高翼，王为善，李珊珊，夏雪奎，刘昌衡，代焕琴，张嗣良*，张立新*. 微生物, 高智商, 大产业——合成生物学助力阿维菌素的高效智能制造. 生命科学, 2018. (特邀论文).
• Yao, Y.#, Li, S.#, Cao, J., Liu, W., Qi, F., Xiang, W., Yang, K.*, Wang, W.* and Zhang LX*. 2018. A novel signal transduction system for development of uric acid biosensors. Appl Microbiol Biotechnol. 102:7489-7497.
• 文莹, 张立新*. 阿维菌素的中国“智”造. 遗传学报, 2018. 40(10):888-899. (特邀论文).
• Wen Y, Zhang LX. Avermectins, intelligently made in China. Yi Chuan. 40(10):888-899. (2018)
• Naowarojna N, Huang P, Cai Y, Song H, Wu L, Cheng R, Li Y, Wang S, Lyu H, Zhang LX, Zhou J, Liu P. 2018. In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions. Org Lett. 20:5427-5430.
• Xu Y, Tan G, Ke M, Li J, Tang Y, Meng S, Niu J, Wang Y, Liu R, Wu H, Bai L, Zhang LX*, Zhang B*. 2018. Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis. J Ind Microbiol Biotechnol. 45(5):345-355.

2017

• Gao Q, Tan GY, Xia X, Zhang LX*. 2017. Learn from microbial intelligence for avermectins   overproduction. Curr Opin Biotechnol. 48:251-257.
• Liu J, Li J, Dong H, Chen Y, Wang Y, Wu H, Li C, Weaver DT, Zhang LX*, Zhang B*. 2017. Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor. Appl Microbiol Biotechnol. 101(14):5773-5783.
• Lpez-Prez B, Ma R, et al. , Zhang LX*, George JR*. 2017. Biosynthetically Guided Structure–Activity Relationship Studies of Merochlorin A, an Antibiotic Marine Natural Product. ChemMedChem 12, 1 – 9. DOI: 10.1002/cmdc.201700451.
• Liu M, Grkovic T, Liu X, Han J, Zhang LX*, Quinn RJ*. 2017. A systems approach using OSMAC, LogP and NMR Fingerprinting: An approach to novelty. Synth Syst Biotechnol. DOI: 10.1016/j.synbio.2017.10.001
• Li, S., Zhou, L., Yao, Y., Fan, K., Li, Z., Zhang LX., Wang, W. * and Yang, K. * (2017) A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. Chem Commun (Camb), 53, 99-102.
• Yang Na , Sun Chaomin*, Zhang LX, Liu Jianguo , and Song Fuhang*. (2017) Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1), Frontiers in Microbiology. 8.
• Han Junjie, Liu Congcong, Li Li, Zhou Hui, Liu Li, Bao Li, Chen Qian, Song Fuhang, Zhang LX, Li Erwei, Liu Ling, Pei Yunfei, Jin Cheng, Xue Yanfen, Yin Wenbing, Ma Yanhe, and Liu Hongwei*. (2017) Decalin-Containing Tetramic Acids and 4-Hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog), The Journal of organic chemistry 82, 11474-11486.
• Zhu Yuying, Huang Pei, Yang Na, Liu Rui, Liu Xueting, Dai Huanqin, Zhang LX, Song Fuhang*, Sun Chaomin*. 2017, Establishment and application of a high throughput screening system targeting the interaction between HCV internal ribosome entry site and human eukaryotic translation initiation factor 3. Frontiers in Microbiology. 8:977-82. doi: 10.3389/ fmicb.2017. 00977. eCollection
• Zhang J, Wang S, Wei Q, Guo Q, Bai Y, Yang S, Song F, Zhang LX, Lei X*. 2017. Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance. Bioorg Med Chem. 25(19):5133-5141
• Qi J B. Zhao, P.P. Zhao, C.H. Liu, Zhang LX*, Xia X*. 2017. Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicas Using Zebrafish Assay. Natural Product Communications, 12（2）:261 – 262
• Zhang Xinjun, He Hhongtao, Ma Rong, Ji Zengchun, Wei Qi, Dai Huanqin, Zhang LX*, Song Fuhang*. Madurastatin B3, a rare aziridine derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity. Journal of Industrial Microbiology & Biotechnology. 2017, 44(4-5):589-594. doi: 10.1007/s10295-017-1908-1.
• He W, Li Y, Qin Y, Tong X, Song Z, Zhao Y, Wei R, Li L, Dai H, Wang W, Luo H, Ye X, Zhang LX*, Liu X*. 2017. New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii. Journal Applied Microbiology and Biotechnology, 101(16), 6365-6374

2016

• Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, Boya P CA, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O’Neill EC, Briand E, Helfrich EJ, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AM, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang LX, Knight R, Jensen PR, Palsson BØ, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. 2016.  Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology. 9;34(8):828-837. doi: 10.1038/nbt.3597.
• Li S, Zhou L, Yao Y, Fan K, Li Z, Zhang LX, Wang W, Yang K. 2016. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. Chem Commun (Camb) 53(1):99-102.
• Tong Y, Liu M, Zhang Y, Liu X, Huang R, Song F, Dai H, Ren B, Sun N, Pei G, Bian J, Jia XM, Huang G, Zhou X, Li S, Zhang B, Fukuda T, Tomoda H, Ōmura S, Cannon RD, Calderone R, Zhang LX*. Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synth Syst Biotechnol. 2016. 1(3):158-168
• Abdel-Mageed WM, et al. Mei Liu, Jingyu Zhang, Zhang LX* , Xueting Liu*. 2016.  Non-Cyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsiachinensis. Organic Letters, 15;18(8):1728-31. doi: 10.1021/acs.orglett.6b00206.
• Liu J, Chen Y, Wang W, Ren M, Wu P, Wang Y, Li C, Zhang LX, Wu H, Weaver DT, Zhang B. 2016. Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. Metab Eng.2016 Oct 26. pii: S1096-7176(16)30186-0. doi: 10.1016/j.ymben.2016.10.012.
• Chen Xing , Ren Biao , Chen Ming , Wang Quanxin , Zhang LX, and Yan Guiying. (2016) NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning, PLoS Comput. Biol. 12-20.
• He W, Liu M, Li X, Zhang X, Abdel-Mageed WM, Li L, Wang W, Zhang J, Han J, Dai H, Quinn RJ, Liu HW, Luo H,  Zhang LX*, Xueting Liu*.  Fungal biotransformation of tanshinone results in [4+2]cycloaddition with sorbicillinol: Evidence for enzyme catalysisand increased antibacterial activity. Applied Microbiology and Biotechnology, 2016. 100(19):8349-57.
• Chen J, Miao J, Liu M, Liu X, Bao L, Jiang Y, Wang D, Zhang Q, Zhang LX*. 2016.  Different fates of avermectin and artemisinin in China. Sci China Life Sci. 59(6):634-6.
• Liu M, Grkovic T, Zhang LX, Liu X*, Quinn RJ*. 2016. A model to predict anti-tuberculosis activity: value proposition for marine microorganisms. J Antibiot (Tokyo). 2016 Jul 13. doi: 10.1038/ja. 2016.87
• Zhang LX *. 2016. Synergistic antibacterial and antifungal activities of avermectins from a proprietary marine natural product library. J Antibiot (Tokyo). 2016 Jan 27. doi: 10.1038/ja. 2016.1
• Fuhang Song, Hongtao He, Rong Ma, Xue Xiao, Qi Wei, Qinqin Wang, d, Zengchun Ji, Huanqin Dai, Zhang LX, Robert J. Capon. 2016. Structure revision of the Penicillium alkaloids haenamindole and citreoindole. Tetrahedron Letters, 34, 3851–3852
• Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Fuhang Song, Huanqin Dai, Jingyu Zhang, Krishna Bolla, Ronald Quinn, Tanja Grkovic, Houwei Luo,  Zhang LX*, Xueting Liu*. 2016. Discovery of tashinone derivatives with anti-MRSA activity via targeted bio-transformation. Synthetic and Systems Biotechnology, doi:10.1016/j.synbio.2016.05.002
• Pei Huang, Feng Xie, Biao Ren, Qian Wang, Jian Wang,Qi Wang, Miaomiao Liu, Jianying Han, Jinzhao Shen, Fuhang Song, Huanqin Dai, Xueting Liu,* Zhang LX*. 2016. Anti-MRSA and anti-TB Metabolites from Marine-derived Verrucosispora sp. MS100047. Appl Microbiol Biotechnol. Mar 15. [Epub ahead of print]
• Zarins-Tutt JS, Barberi TT, Gao H, Mearns-Spragg A, Zhang LX, Newman DJ, Goss RJ. 2016. Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products. Nat Prod Rep. 33(1):54-72
• Chen J, Liu M, Miao J, Fu C, He H, Müller R, Zhang Q, Zhang LX*. 2016. Interrogation of Streptomyces avermitilis for efficient production of avermectins. Synthetic and Systems Biotechnology, 1(1):7-16,doi:10.1016/j.synbio.2016.03.002
• Zhang LX*. 2016. Uprising of Synthetic and Systems Biotechnology. Synthetic and Systems Biotechnology, 1(1):1-2
• Hang Wu, Yansheng Wang, Li Yuan, Yongrong Mao, Weiwei Wang, Lin Zhu, Panpan Wu, Chengzhang Fu, Rolf Müller, Weaver DT*,  Zhang LX*, Zhang B*. 2016. Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea. Synthetic and Systems Biotechnology, 1(1):39-46
• Wen-Ru Li, Qingshan Shi, Huan-Qin Dai, Qing Liang, Xiao-Bao Xie, Xiao-Mo Huang, Guang-Ze Zhao, Zhang LX*. 2016. Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans. Scientific Reports,  Mar 7;6:22805. doi: 10.1038/srep22805.
• Chen J, Miao J, Zhang L*. 2016. From the Nobel Prize winning molecule avermectin to innovation China. Acta Microbiologica Sinica, 56(3): 1-8
• Wu H, Li W, Xin C, Zhang C, Wang Y, Ren S, Ren M, Zhao W, Yuan L, Xu Z, Yuan H, Geng M, Zhang L, Weaver DT, Zhang B*. 2016. In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 100(5):2257-66.
• Wu Y, Min F, Pan J, Wang J, Yuan W, Zhang Y, Huang R, Zhang L*. 2016. Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole. Vet Med Int. 370641. doi: 10.1155/2015/370641. [Epub ahead of print].
• Wang Kai , Bao Li , Ma Ke , Qi Wei , Song Fuhang , Yao Yijian , Yin Wenbing , Zhang L, Huang Ying , Han Junjie , and Liu Hongwei*. (2016) Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp Collected in the Tibet Plateau Region, Eur. J. Org. Chem., 4338-4346.  
• Abdel-Mageed WM, Mohamed NH, Liu M, El-Gamal AA, Basudan OA, Ismail MA, Quinn RJ, Liu X*, Zhang L*, Shoreit AA*. 2016. Lipoxygenase inhibitors from the latex of Calotropis procera. Arch Pharm Res. 2016 Mar 9. [Epub ahead of print]
• Li S, Zhou L, Yao Y, Fan K, Li Z, Zhang L, Wang W, Yang K. 2016. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. Chem Commun (Camb). 53(1):99-102.

2015

• Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang L, Pinghua Liu, and Yan Jessie Zhang*. 2015. Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme. Nature, 527, 539–543.
• Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C, Zhang L. 2015. Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A. 112 (39), 12181-6.
• Wang F, Wang Y, Ji J, Zhou Z, Yu J, Zhu H, Su Z, Zhang L, Zheng J. 2015. Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase. ACS Chem Biol. 10(4):1017-25
• Mohamed NH, Liu M, Abdel-Mageed WM, Alwahibi LH, Dai H, Ismail MA, Badr G, Quinn RJ, Liu X, Zhang L, Shoreit AA*. 2015. Cytotoxic cardenolides from the latex of Calotropis procera. Bioorg Med Chem Lett. 25(20):4615-20.
• Romero C. A., Grkovic T., Han J., Zhang L, French J. R. J., Kurtboke D. I., and Quinn R. J.*. 2015. NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species, RSC Adv. 5, 104524-104534.
• Wu Yu’e, Min Fangui, Pan Jinchun, Wang Jing, Yuan Wen, Zhang* Yu, Huang* Ren, and Zhang* Lixin. Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole, Veterinary medicine international 2015, 1-7.
• Na Yang, Zhang L, Chaomin Sun. 2015. Algoriella xinjiangensis gen. nov., sp. nov., a new psychrotoleran bacterium of the family Flavobacteriaceae. Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 108:1107–1116.
• Tong, Yaojun; Charusanti, Pep; Zhang L, Weber, Tilmann; Lee, Sang Yup*. 2015. CRISPR-Cas9 based engineering of actinomycetal genomes. ACS Synthetic Biology. 4(9):1020-9.
• Lin, J., Nishino, K., Roberts, M. C., Tolmasky, M., Aminov, R. I., and Zhang L*, eds. (2015). Mechanisms of Antibiotic Resistance. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-526-8
• Zhang XM, Guo H, Li ZS, Song FH, Dai HQ, Zhang L, Wang JG. 2015. Synthesis and evaluation of isatin-b-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species. European b-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species. European Journal of Medicinal Chemistry 101: 419-430.
• Chakraborty S, Ghosh M, Chakraborti S, Jana S, Sen KK, Kokare C, Zhang L. (2015) Biosurfactant produced from Actinomycetes nocardiopsis A17: Characterization and its biological evaluation. Int J Biol Macromol. 16:405-412.
• Cui J, Ren B, Tong Y, Dai H, Zhang L*. 2015. Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence. 6(4):362-71.
• Mao Yongrong Wu Hang, Chen Meng, Pan Hui, Huang Xunduan, Ren Min, Wu Hao, Li Jiali, Xu Zhongdong,
• Yuan Hualing, Geng Ming, Weaver David T., Zhang L, Zhang Buchang. (2015) Capturing the target genes of BldD in Saccharopolyspora erythraea using improved genomic SELEX method, Appl. Microbiol. Biotechnol. 99, 2683-2692
• Lin Jun, Nishino Kunihiko, Roberts Marilyn C, Tolmasky Marcelo, Aminov Rustam I, Zhang L*. (2015) Mechanisms of antibiotic resistance, Frontiers in microbiology 6, 34.
• Chakraborty Samrat, Ghosh Mandakini, Chakraborti Srijita, Jana Sougata, Sen Kalyan Kumar, Kokare Chandrakant, and Zhang L*. (2015) Biosurfactant produced from Actinomycetes nocardiopsis A17: Characterization and its biological evaluation, International journal of biological macromolecules 79, 405- 412.
• Pengwei Li, Jine Li, Zhengyan Guo, Wei Tang, Jianshan Han, Xiangxi Meng, Tingting Hao, Yaxin Zhu, Zhang L, Yihua Chen, 2015, An efficient blue-white screening based gene inactivation system for Streptomyces, Applied Microbiology and Biotechnology, 99, 4, 1923.
• Xie F, Dai S, Shen J, Ren B, Huang P, Wang Q, Liu X, Zhang B, Dai H, Zhang L. 2015. A new salicylate synthase AmS is identified for siderophores biosynthesis in Amycolatopsis methanolica 239T. Appl Microbiol Biotechnol. 99:5895–5905
• Han J, Zhang J, He W, Huang P, Oyeleye A, Liu X, Zhang L. 2015. Bioassay-guided identification of bioactive molecules from traditional Chinese medicines.Methods Mol Biol. 1263:187-96.
• Xiao-Yun Yu, Li Zhang, Biao Ren, Na Yang, Mei Liu, Xue-Ting Liu, Zhang L* and Lin-Xian Ding*. 2015. Arthrobacter liuii sp. nov., resuscitated from Xinjiang desert soil. Int J Syst Evol Microbiol 65: 896-901
• Na Yang,Lixin Zhang,Chaomin Sun, 2015, Algoriella xinjiangensis gen. nov., sp. nov., a new psychrotolerant bacterium of the family Flavobacteriaceae. Antonie van Leeuwenhoek Pub Date : 2015-08-28 , DOI: 10.1007/s10482-015-0564-6
• Jingyu Zhang,Jianying Han,Ayokunmi Oyeleye,Miaomiao Liu,Xueting Liu,Lixin Zhang, 2015, Extraction methods of natural products from Traditional Chinese medicines. Methods in molecular biology (Clifton, N.J.) Pub Date : 2015-01-27 ,DOI:10.1007/978-1-4939-2269-7_14
• Jianying Han,Jingyu Zhang,Wenni He,Pei Huang,Ayokunmi Oyeleye,Xueting Liu,Lixin Zhang, 2015, Bioassay-guided identification of bioactive molecules from traditional Chinese medicines. Methods in molecular biology (Clifton, N.J.) Pub Date : 2015-01-27 ,DOI:10.1007/978-1-4939-2269-7_15

2014

• Kyrpides Nikos C, Zhang Lixin, Klenk Hans-Peter. (2014) Genomic encyclopedia of bacteria and archaea: sequencing a myriad of type strains. PLoS biology 12(8):e1001920. IF=12.807
• Zhang HM, Dai H, Hanson PJ, Li H, Guo H, Ye X, Hemida MG, Wang L, Tong Y, Qiu Y, Liu S, Wang F, Song F, Zhang B, Wang JG, Zhang LX, Yang D. Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-Mediated Suppression of Cap-Independent Translation. ACS Chem Biol. 2014 18;9(4):1015-24. IF=5.44
• Wu Hang, Chen Meng, Mao Yongrong, Li Weiwei, Liu Jingtao, Huang Xunduan, Zhou Ying, Ye Bang-Ce, Zhang Lixin, David T Weaver, Zhang Buchang*. (2014) Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea. Microbial Cell Factories，13(1):158-169 IF=4.566
• Ren Biao, Dai Huanqin, Pei Gang, Tong Yaojun, Zhuo Ying, Yang Na, Su Mengyi, Huang Pei, Yang Yuzhuo, Zhang Lixin*. (2014) ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility. Appl Microbiol Biotechnol Jan 17. IF=4.138
• Chen Xing#, Ren Biao#, Chen Ming, Liu Mingxi, Ren Wei, Wang Quanxin, Zhang Lixin, Yan Guiying. (2014) ASDCD: Antifungal Synergistic Drug Combination Database. PLoS ONE 9(1): e86499. doi:10.1371/journal.pone.0086499 IF=4.015
• Guo Hui, Ren Biao, Dai Huanqin, Dai Shengwang, Zhang Yuhan, Liu Yingmei, Cao Bin, Zhang Lixin*. (2014) Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. International journal of antimicrobial agents.44(3):274-279 IF=4.141
• Chen X, Ren B, Chen M, Liu M-X, Ren W, Wang Q, Zhang L, Yan G. 2014. ASDCD: Antifungal Synergistic Drug Combination Database. PLoS ONE 9(1): e86499. doi:10.1371/journal.pone.0086499.IF=3.73
• Song F, Ren B, Chen C, Yu K, Liu X, Zhang Y, Yang N, He H, Liu X, Dai H, Zhang L*. 2014. Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359. Appl Microbiol Biotechnol. 2014 Jan 24. [Epub ahead of print]IF=3.61
• Miaomiao Liu, Wael M. Abdel-Mageed, Biao Ren, Wenni He, Pei Huang, Xiaolin Li, Krishna Bolla, HuiGuo, Caixia Chen, Fuhang Song, Huanqin Dai, TanjaGrkovic, Xiaoping Zhang,* Xueting Liu,* Li-Xin Zhang*. 2014. AntitubercularPluramycins from Endophytic Streptomyces sp. Y3111. Applied Microbiology and Biotechnology [Epub ahead of print].IF=3.61
• Abdel-Mageed Wael M, Bayoumi Soad A H, Chen Caixia, Vavricka Christopher J, Li Li, Malik Ajamaluddin, Dai Huanqin, Song Fuhang, Wang Luoqiang, Zhang Jingyu, George F Gao, Lv Yali, Liu Lihong, Liu Xueting, Sayed Hanaa M, Zhang Lixin *. (2014) Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity. Bioorganic & medicinal chemistry，April 1, 22(7): 2236-2243 IF=3.205
• Wu Panpan, Pan Hui, Zhang Congming, Wu Hang, Yuan Li, Huang Xuanduan, Zhou Ying, Ye Bang-ce, Weaver David T, Zhang Lixin, Zhang Buchang. (2014) SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 41(7):1159-1167 IF=2.873
• Yang Na, Ren Biao, Liu Zhiheng, Dai Huanqin, Wang Jian, Zhou Yuguang, Song Fuhang* and Zhang Lixin*. (2014) Salinibacillus xinjiangensis sp. nov., a halophilic bacterium from a hypersaline lake. Int J Syst Evol Microbiol 64, 27–32, DOI 10.1099/ijs.0.053306-0 IF=2.632
• Liu Mei #, Zhang Li#, Ren Biao, Yang Na, Yu Xiaoyun, Wang Jian, Ding Linxian, Liu Xueting, Liu Zhiheng, Michael Goodfellow and Zhang Lixin*. (2014) Prauserella shujinwangiisp. nov., from a desert Environment. International Journal of Systematic and Evolutionary Microbiology, 64:3833–3837 IF=2.632
• Yu Xiaoyun#, Zhang Li# , Ren Biao, Yang Na, Liu Mei, Liu Xueting, Zhang Lixin, Ding Linxian . (2014) Arthrobacter liuii sp. nov., resuscitated from 1 Xinjiang desert soil. International Journal of Systematic and Evolutionary Microbiology. IF=2.632
• Vikramjeet Singh#, Amita Nand#, Chen Caixia, Li Zhipeng, Li Sheng-Jie, Songbai Wang, Yang Mo, Alejandro Merino, Zhang Lixin and Zhu Jingsong*. (2014) Echinomycin, a Potential Binder of FKBP12, Shows Minor Effect on Calcineurin Activity. Journal of biomolecular screening Oct19(9):1275-81 doi: 10.1177/1087057114544742 IF=2.107
• Li Xiaolin, Huang Pei, Wang Qian, Xiao Lie, Liu Miaomiao, Krishna Bolla, Zhang Bo, Zheng Linyong, Gan Bingcheng, Liu Xueting, Zhang Lixin and Zhang Xiaoping*. (2014) Staurosporine from the endophytic Streptomyces sp. strain CNS-42 acts as a potential biocontrol agent and growth elicitor in cucumber. Antonie van Leeuwenhoek106:515-525 IF=2.072
• Xu Xiuli, Yin Liyuan, Gao Junhai, Gao Lijie and Song Fuhang.(2014) Antifungal Bromophenols from Marine Red Alga Symphyocladia latiuscula.Chemistry & Biodiversity 11:807-811 IF=1.957
• ZhuoYing, Zhang Tao, Wang Qi, Cruz-Morales P, Zhang B, Liu M, Barona-Gómez F, Zhang Lixin*. (2014) Synthetic biology of avermectin for production improvement and structure diversification. Biotechnology Journal. 9(3) :316-325.
• Ying Zhuo,Tao Zhang,Qi Wang,Pablo Cruz-Morales,Buchang Zhang,Mei Liu,Francisco Barona-Gómez,Lixin Zhang, 2014, Synthetic biology of avermectin for production improvement and structure diversification. Biotechnology Journal ( IF 3.543 ) Pub Date : 2014-01-31 , DOI: 10.1002/biot.201200383

2013

• Qian Wang, Fuhang Song, Xue Xiao, Pei Huang, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Jian Wang, HuiGuo, Wenni He, FengXie, Huanqin Dai, Miaomiao Liu, Caixia Chen, HaoXu, Mei Liu, Andrew M. Piggott, Xueting Liu, Robert J. Capon, Li-Xin Zhang*. 2013. Abyssomicins from a South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as potential antitubercular prodrugs. Angew. Chem.-Int. Edit. 52, 1231-1234.IF=13.555
• Xie J, Nobile CJ, Tong Y, Kourkoumpetis TK, Johnson AD, Zhang L, Bai FY, Huang G. 2013. White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex. PLoS Biol 11(3): e1001525. IF=13.7
• Chen Caixia, Liu Xueting, Abdel-Mageed Wael M, Guo Hui, Hou Weiyuan, Jaspars Marcel, Li Li, Xie Feng, Ren Biao, Wang Qian, Dai Huanqin, Song Fuhang*, Zhang Lixin *. 2013. Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus. Organic Letters. 15 (15), pp 3982-3985, DOI: 10.1021/ol402773310.1021/ol401736z) IF=5.563
• Zhang Jingyu, Abdel-mageed Wael M., Liu Miaomiao, Huang Pei, He Wenni, Li Li, Song Fuhang, Dai Huanqin, Liu Xueting, Jingyu Liang, Zhang Lixin*. 2013. Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan. Organic Letters. 15(18), 4726-4729. IF=5.563
• Wang QX, Qi QY, Wang K, Li L, Bao L, Han JJ, Liu MM, Zhang L, Cai L, Liu HW. 2013. Coicenals A-D, Four New Diterpenoids with New Chemical Skeletons from the Plant Pathogenic Fungus Bipolaris coicis. Org Lett. 2013 Jul 22. [Epub ahead of print] IF=5.563
• Tong Yaojun, Cao Chengjun, Xie Jing, Ni Jian, Guan Guobo, Tao Li, Zhang Lixin, Huang Guanghua. 2013. N-acetylglucosamine-induced white-to-opaque switching in Candida albicans is independent of the Wor2 transcription factor. Fungal Genetics and Biology. (In press) IF=3.379
• Qi Wang, Biao Tang, Lifu Song, Biao Ren, Qun Liang, Feng Xie, Ying Zhuo, Xueting Liu and Lixin Zhang. 2013. 3DScapeCS: application of three dimensional, parallel, dynamic network visualization in Cytoscape. BMC Bioinformatics. 2013. 14;14:322. IF=3.02
• Liu Xinru., Song Fuhang., Ma Li, Chen Caixia, Xiao Xue, Ren Biao, Liu Xueting, Dai Huanqin, Piggott Andrew M., Av-Gay Yossef, Zhang Lixin, Capon Robert J. 2013. Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii. Tetrahedron Letters. 54,6081-6083. IF=2.376
• He S, Li-Xin Zhang*. 2013. Tentative biosynthetic pathways of some microbial diketopiperazines. Appl Microbiol Biotechnol. 2013 Aug 2. [Epub ahead of print]
• Zhang T, Zhuo Y, Jia X, Liu J, Gao H, Song F, Liu M, Zhang L. Cloning and characterization of the gene cluster required for beauvericin biosynthesis in Fusarium proliferatum. Sci China Life Sci. 2013 Jul;56(7):628-37. doi: 10.1007/s11427-013-4505-1. Epub 2013 Jul 6.
• Yang N, Ren B, Dai H, Liu Z, Zhou Y, Song F, Zhang L. Gracilibacillus xinjiangensis sp. nov., a new member of the genus Gracilibacillus isolated from Xinjiang region, China. Antonie Van Leeuwenhoek. 2013 Aug 7. [Epub ahead of print]
• Hsu CC, Elnaggar MS, Peng Y, Fang J, Sanchez LM, Mascuch SJ, Møller KA, Alazzeh EK, Pikula J, Quinn RA, Zeng Y, Wolfe BE, Dutton RJ, Gerwick L, Zhang L, Liu X, Månsson M, Dorrestein PC. 2013. Real-Time Metabolomics on Living Microorganisms Using Ambient Electrospray Ionization Flow-Probe.Anal Chem. 2013 Jul 11. [Epub ahead of print]
• Wang QX, Yang JL, Qi QY, Bao L, Yang XL, Liu MM, Huang P, Zhang L, Chen JL, Cai L, Liu HW. 2013. 3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorg Med Chem Lett. 23(12):3547-50
• Liu X, Biswas S, Berg MG, Antapli CM, Xie F, Wang Q, Tang MC, Tang GL, Zhang L, Dreyfuss G, Cheng YQ. 2013. Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43. J Nat Prod. 26;76(4):685-93.IF=3.128
• Chen C, Wang J, Guo H, Hou W, Yang N, Ren B, Liu M, Dai H, Liu X, Song F, Li-Xin Zhang*. 2013. Three antimycobacterial metabolites identified from a marine-derived Streptomyces sp. MS100061. Appl Microbiol Biotechnol. 97(9):3885-92.IF=3.829
• Shang JL, Guo H, Li ZS, Ren B, Li ZM, Dai HQ, Li-Xin Zhang*, Wang JG. 2013. Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents. Bioorg Med Chem Lett. 23(3):724-7.
• Wang QX, Bao L, Yang XL, Guo H, Ren B, Guo LD, Song FH, Wang WZ, Liu HW, Li-Xin Zhang*. 2013. Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method. Fitoterapia. 85:8-13.
• Tang B, Wang Q, Yang M, Xie F, Zhu Y, Zhuo Y, Wang S, Gao H, Ding X, Li-Xin Zhang*, Zheng H, Zhao GP. 2013. ContigScape: a Cytoscape plugin facilitating microbial genome gap closing. BMC genomics, 14(1):289.
• Xinru Liu; Fuhang Song; Li Ma; Caixia Chen; Xue Xiao; Biao Ren; Xueting Liu; Huanqin Dai; Andrew M. Piggott; Yossef Av-Gay; Lixin Zhang; Robert J. Capon; 2013, Sydowiols A–C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii Tetrahedron Letters ( IF 2.259) Pub Date : 6 November , DOI: 10.1016/j.tetlet.2013.08.137
• Sasikumar Arunachalam Palaniyandi,Seung Hwan Yang,Lixin Zhang,Joo-Won Suh; 2013, Effects of actinobacteria on plant disease suppression and growth promotion. Applied Microbiology and Biotechnology (IF 3.67) Pub Date : 2013-10-05 ,DOI:10.1007/s00253-013-5206-1
• Nuo Sun,Dongmei Li,William Fonzi,Xin Li,Lixin Zhang,Richard Calderone, 2013, Multidrug-resistant transporter mdr1p-mediated uptake of a novel antifungal compound. Antimicrobial agents and chemotherapy Pub Date : 2013-09-18 ,DOI:10.1128/aac.01504-13
• Jane Y. Yang, Laura M. Sanchez, Christopher M. Rath, Xueting Liu, Paul D. Boudreau, Nicole Bruns, Evgenia Glukhov, Anne Wodtke, Rafael de Felicio, Ama Fenner, Weng Ruh Wong, Roger G. Linington, Lixin Zhang, Hosana M. Debonsi, William H. Gerwick, Pieter C. Dorrestein, 2013, Molecular Networking as a Dereplication Strategy Journal of Natural Products ( IF 4.257 ) Pub Date : 2013-09-11 , DOI: 10.1021/np400413s
• Ghanshyam Raut, Sachin Vetal, Ren Biao, Xiang-Yang Liu, Lixin Zhang, Chandrakant Kokare, 2013, Retraction notice to “Purification and characterization of organic solvent and detergent stable protease isolated from marine Saccharopolyspora sp. A9: Application of protease for wound healing” [Biochem. Eng. J. 69 (2012) 196–203] Biochemical Engineering Journal (IF 3.371) Pub Date : 2013-06-03 ,DOI:10.1016/j.bej.2013.05.003

2012

• Song F, Liu X, Guo H, Ren B, Chen C, Piggott AM, Yu K, Gao H, Wang Q, Liu M, Liu X, Dai H, Zhang*, L., Capon RJ. 2012, Brevianamides with Antitubercular Potential from a Marine-Derived Isolate of Aspergillus versicolor. Org Lett. 14(18):4770-3. Epub 2012 Sep 10.IF=5.862
• SUN Nuo, William Fonzi, CHEN Hui, SHE Xiaodong, ZHANG Lulu, ZHANG Lixin, Richard Calderone*. Azole susceptibility and transcriptome profiling in the Candida albicans mitochondrial electron transport chain complex I mutants. Antimicrobial Agents Chemotherapy. 2012, doi:10.1128/AAC.01520-12.IF=4.841
• Goodfellow Michael*, Roselyn Brown, Lina Ahmed, Wasu Pathom-aree, Alan T. Bull, Amanda L. Jones, James E. M. Stach, Tiago Domingues Zucchi, ZHANG Lixin, WANG Jian. Verrucosispora fiedleri sp. nov., an actinomycete isolated from a fjord sediment which synthesizes proximicins. Antonie Van Leeuwenhoek. 2012 Oct 31. [Epub ahead of print] DOI 10.1007/s10482-012-9831-y.IF=2.091
• Ren B, Yang N, Wang J, Ma XL, Wang Q, Xie F, Guo H, Liu ZH, Pugin B, Zhang*, L., 2012, Amphibacillus marinus sp. nov., a new member of the genus Amphibacillus isolated from the South China Sea. Int J Syst Evol Microbiol. Aug 3. [Epub ahead of print]IF=2.268
• Liu X, Chen C, He W, Huang P, Liu M, Wang Q, Guo H, Bolla K, Lu Y, Song F, Dai H, Liu M, Zhang*, L., 2012, Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants. Antonie Van Leeuwenhoek. 102(3):447-61. Epub 2012 Jul 20.IF=2.091
• Zhuo Y, Liu L, Wang Q, Liu X, Ren B, Liu M, Ni P, Cheng YQ, and Zhang*, L., 2012, Revised Genome Sequence of Burkholderia thailandensis MSMB43 with Improved Annotation. Journal of Bacteriology. 194 (17): 4749-50.IF=3.825
• Ma L, Liu X, Liang H, Che Y, Chen C, Dai H, Yu K, Liu M, Ma L, Yang CH, Song F, Wang Y, and L Zhang*. 2012. Molecular targets of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy . Jul 16. [Epub ahead of print].IF=4.841
• Song F, Ren B, Yu K, Chen C, Guo H, Yang N, Gao H, Liu X, Liu M, Tong Y, Dai H, Bai H, Wang J, Zhang*, L., 2012, Quinazolin-4-one coupled with pyrrolidin-2-iminium alkaloids from marine-derived fungus Penicillium aurantiogriseum. Mar Drugs. 10(6):1297-306. Epub 2012 Jun 7.
• Zhang T, Jia X, Zhuo Y, Gao H, Liu M, Liu J, Zhang*, L., 2012, Cloning and characterization of a novel 2-ketoisovalerate reductase from the beauvericin producer Fusarium proliferatum LF061. BMC Biotechnol. 12(1):55. [Epub ahead of print]IF=2.349
• Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A, Zhang*, L., 2012, Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 75(9):1534-8. Epub 2012 Aug 30.IF=3.128
• Wang Quanxin, Bao Li, Yang Xiaoli, Guo Hui, Yang Ruinan, Ren Biao, Zhang Lixin, Dai Huanqin, Guo Liangdong, Liu Hongwei. 2012. Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp. Fitoterapia. 83(1):209-214.
• Khopade Abhijit, Ren Biao, Liu Xiangyang, Mahadik K, Zhang Lixin , Kokare Chandrakant. 2012. Production and characterization of biosurfactant from marine Streptomyces species B3. J Colloid Interface Sci. 367(1):311-318.
• Abhijit Khopade, Ren Biao, Xiang-Yang Liu, Kakasaheb Mahadik, Lixin Zhang, Chandrakant Kokare*. 2012. Production and characterization of biosurfactant from marine Streptomyces species B3. Journal of Colloid and Interface Science. doi:10.1016/j.jcis.2011.11.009 IF=3.068
• Khopade Abhijit, Ren Biao, Liu Xiangyang, Mahadik Kakasaheb, Zhang Linxin, Kokare Chandrakant*. 2012. Production and stability studies of the biosurfactant isolated from marine Nocardiopsis sp. B4. Desalination. 285:198 – 204.
• Polyak SW*, Abell AD, Wilce MCJ, Zhang Lixin, Booker GW. 2012. Structure, function and selective inhibition of bacterial acetyl-coa carboxylase. Appl Microbiol Biotechnol. 93(3):983-992.
• Yang Na, Ren Biao, Wang Jian, Zhang Lixin *. 2012. Isolation of novel natural products from un- or underexplored marine actinomycetes. The Bulletin of BISMiS. 2(2): 181-8
• Liu Xueting, Bolla Krishna, Ashforth Elizbeth Jane, Zhuo Ying, Gao Hong, Huang Pei, Stanley Sarah A, Hung Deborah T, Zhang Lixin*. 2012. Systematics-guided bioprospecting for bioactive microbial natural products. Antonie van Leeuwenhoek. 101(1): 55-66. IF=1.673
• Zvarec Ondrej, Polyak Steven W, Tieu William, Kuan Kevin, Dai Huanqin, Daniel Sejer Pedersen, Morona Renato, Zhang Lixin, Booker Grant W, Abell Andrew D*. 2012. 5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials. Bioorg Med Chem Lett. 22: 2720–2722.
• Xie Jing, Du Han, Guan Guobo, Tong Yaojun, Kourkoumpetis Themistoklis K, Zhang Lixin, Bai Fengyan, Huang Guanghua. 2012. N-Acetylglucosamine Induces White-to-Opaque Switching and Mating in Candida tropicalis Providing New Insights into Adaptation and Fungal Sexual Evolution. Eukaryot Cell. doi: 10.1128/EC.00047-12.
• Du Han, Guan Guobu, Xie Jing, Sun Yuan, Tong Yaojun, Zhang Lixin, Huang Guanghua* . 2012. Roles of Candida albicans Gat2, a GATA-Type Zinc Finger Transcription Factor, in Biofilm Formation, Filamentous Growth and Virulence. Plos One, 7 (1): e29707.
• Chen Caixia, Song Fuhang, Wang Qian, Abdel-Mageed Wael Mostafa, Guo Hui, Fu Chengzhang, Hou Weiyuan, Dai Huanqin, Liu Xueting, Yang Na, Xie Feng, Yu Ke, Chen Ruxian, Zhang Lixin *. 2012. A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X(2) and actinomycin D with potent anti-tuberculosis activity. Appl Microbiol Biotechnol. 2012 Apr 28. [Epub ahead of print]IF=3.613
• Zhou Yanmi, He Ping, Liu Aiming, Zhang Lixin, Liu Yunde, Dai Renke*. Drug-drug Interactions between Ketoconazole and Berberine in Rats: Pharmacokinetic Effects Benefit Pharmacodynamic Synergism. Phytother Res. 2012 May;26(5):772-7. doi: 10.1002/ptr.3621.
• Chen Caixia, Song Fuhang, Guo Hui, Abdel Mageed Wael Mostafa, Bai Hua, Dai Huanqin, Liu Xueting, Wang Jian, Zhang Lixin, 2012, Isolation and Characterization of LS1924A, a new Q1 analog of emycins. The Journal of Antibiotics. 2012 May 9. doi: 10.1038/ja.2012.39. [Epub ahead of print].
• Yan Yongming, Dai Huanqin, Du Yuhong, Schneider Bernd, Guo Hui, Li Dianpeng, Zhang Lixin. Fu Hai’an, Dong Xiaoping, ChengYongxian. 2012, Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. Bioorganic & Medicinal Chemistry Letters DOI: 10.1016/j.bmcl.2012.04.027.
• Ibraheim Zedan Zeid, Abdel-Mageed Wael M, Dai Huanqin, Guo Hui, Zhang Lixin, Jaspars Marcel. 2012. Antimicrobial Antioxidant Daucane Sesquiterpenes from Ferula hermonis Boiss. Phytother Res. 2012 Apr; 26(4):579-586. doi: 10.1002/ptr.3609. Epub 2011 Sep 26.
• Liu Xiangyang, Ren Biao Gao Hong Liu Mei, Dai Huanqin, Song Fuhang,Yu Zhenyan, Wang Shujin, Hu jiangchun, Zhang lixin*, 2012, Optimization for the production of surfactin with a new synergistic antifungal activity. Plos One, 7(5): e34430. doi:10.1371/journal.pone.0034430
• Biao Tang,Wei Zhao,Huajun Zheng,Ying Zhuo,Lixin Zhang,Guo-Ping Zhao, 2012, Complete genome sequence of Amycolatopsis mediterranei S699 based on de novo assembly via a combinatorial sequencing strategy. Journal of bacteriology Pub Date : 2012-09-27, DOI:10.1128/jb.01295-12
• Sarah A. Stanley, Sarah Schmidt Grant, Tomohiko Kawate, Noriaki Iwase, Motohisa Shimizu, Carl Wivagg, Melanie Silvis, Edward Kazyanskaya, John Aquadro, Aaron Golas, Michael Fitzgerald, Huanqin Dai, Lixin Zhang, Deborah T. H, 2012, Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening. ACS Chemical Biology ( IF 4.374 ) Pub Date : 2012-05-21 , DOI: 10.1021/cb300151m

2011

• Ke Yu, Biao Ren, Junli Wei, Caixia Chen, Jinsheng Sun, Fuhang Song, Huanqin Dai, Lixin Zhang*. 2011. Verrucisidin A and B, Two Pyrone-type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum. Marine drugs. 8(11):2744-54. IF=3.471
• Yaqi Wang, Li Bao, Xiaoli Yang, Hui Guo, Huanqin Dai, Hao Gao, Xinsheng Yao, Lixin Zhang, and Hongwei Liu*. 2011. New Cuparene-Type Sesquiterpenes from Flammulina velutipes. Helvetica Chimica Acta 64(7):932-4. (doi: 10.1002/hlca.201100289) IF=1.284
• Hong Gao, Zhiheng Liu, Lixin Zhang*, Secondary metabolism in simulated microgravity and space flight, Protein &Cell, 2011 , 2(11):858-61
• Samrat C, Khopade Abhijeet, Biao Ren, Wang Jian, Liu X, Zhang Lixin, Chopade Balasaheb, Mahadik Kakasaheb, Kokare Chandrakant. 2011. Studies on calcium independent, thermostable, surfactant, detergent and oxidant stable amylase from haloalkaliphilic marine Streptomyces sp. A3. Microbiological Research. 68:52-58. IF=1.958
• Zhiheng Liu, Jian Wang and Lixin Zhang*. 2011. Advances in actinobacterial systematic taxonomy in genomic Era. Acta Microbiologica Sinica, 51(2):141-153.
• Jianfan Qiu, Ying Zhuo, Dongqing Zhu, Xiufen Zhou, Lixin Zhang, Linquan Bai, Zixin Deng. 2011. Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2011 Jun 29. IF=3.280
• Wen Wu, Huanqin Dai, Li Bao, Biao Ren, Jingcai Lu, Yuanming Luo, Liangdong Guo, Lixin Zhang, and Hongwei Liu*, 2011. Isolation and structural elucidation of Proline-Containing cyclopentapeptides from an Endolichenic Xylaria sp. Jounal of Natural Products. 74:1303-1308. IF=1.586
• Chengzhang Fu, Yongfei Hu, Feng Xie, Hui Guo, Elizabeth Jane Ashforth, Steven W. Polyak, Baoli Zhu, Lixin Zhang*. 2011. Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library. Appl Microbiol Biotechnol. 90(3): 961-970. IF=3.280
• Qirong Tang, Na Yang, Jian Wang, Yuqing Xie, Biao Ren, Yuguang Zhou, Meiying Gu, Jun Mao, Wenjun Li, Yuhu Shi, and Lixin Zhang*. 2011. Paenibacillus algorifonticola sp. nov., isolated from a cold spring in China. Int J Syst Evol Microbiol. 61(9): 2167-2172. IF=1.930
• Quanxin Wang, Saifei Li, Feng Zhao, Huanqin Dai, Li Bao , Rong Ding , Hao Gao, Lixin Zhang, Hua’an Wen, Hongwei Liu. 2011. Chemical constituents from endophytic fungus fusarium oxysporum. Fitorerapia. 82: 777–781. IF=1.899
• Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, and Lixin Zhang*. 2011. Synergistic effect of 14-AL Andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 55(6):3015-3017. IF=4.672
• Danielle M. Williams, Heath Ecroyd, Katy L. Goodwin, Huanqin Dai, Haian Fu, Joanne M. Woodcock, Lixin Zhang, John A. Carver. 2011. NMR spectroscopy of 14-3-3 reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine binding activities of 14-3-3. Biochemical Journal. 437(3):493-503. IF=5.016
• Mei Liu, Hong Gao, Peng Shang, Xianlong Zhou, Elizabeth Ashforth, Ying Zhuo, Difei Chen, Biao Ren, Zhiheng Liu and Lixin Zhang*. 2011. Magnetic Field Is the Dominant Factor to Induce the Response of Streptomyces avermitilis in Altered Gravity Simulated by Diamagnetic Levitation. PLoS One. PLoS One. 2011;6(10):e24697. Epub 2011 Oct 19. IF=4.411
• Polyak SW, Abell AD, Wilce MC, Zhang L, Booker GW. 2011. Structure, function and selective inhibition of bacterial acetyl-coa carboxylase. Appl Microbiol Biotechnol. 2011 Dec 20. IF=3.280
• Jing Zhao , Yuhong Du, John R. Horton, Anup K. Upadhyay, Bin Lou, Yan Bai, Xing Zhang, Lupei Du, Minyong Li, Binghe Wang, Lixin Zhang, Joseph T. Barbieri, Fadlo R. Khuri, Xiaodong Cheng, and Haian Fu et al. 2011. Discovery and structural characterization of FOBISIN 101 as a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci U S A. (on line:doi 10.1073/pnas.1100012108). IF=9.771
• Zedan Zeid Ibraheim,Wael M Abdel-Mageed,Huanqin Dai,Hui Guo,Lixin Zhang,Marcel Jaspars 2011 Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss. Phytotherapy Research Pub Date : 2011-09-29,DOI:10.1002/ptr.3609
• Samrat Chakraborty; Abhijeet Khopade; Ren Biao; Wang Jian; Xiang-Yang Liu; Kakasaheb Mahadik; Balasaheb Chopade; Lixin Zhang; Chandrakant Kokare 2011 Characterization and stability studies on surfactant, detergent and oxidant stable α-amylase from marine haloalkaliphilic Saccharopolyspora sp. A9 Journal of Molecular Catalysis B: Enzymatic ( IF 2.128 ) Pub Date : 2011 , DOI: 10.1016/j.molcatb.2010.09.009
• Hong Gao,Ying Zhuo,Elizabeth Ashforth,Lixin Zhang 2011 Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites. Protein & cell Pub Date : 2011-01-05 ,DOI:10.1007/s13238-010-0073-3
• Xiangyang Liu,Xinyi Tao,Aihua Zou,Shizhong Yang,Lixin Zhang,Bozhong Mu 2011 Effect of the microbial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane. Protein & cell Pub Date : 2011-01-05, DOI: 10.1007/s13238-010-0072-4

2010

• Ying Zhuo, Wenquan Zhang, Difei Chen, Hong Gao, Jun Tao, Mei Liu, Zhongxuan Gou, Xianlong Zhou, Bangce Ye, Qing Zhang, Siliang Zhang, and L Zhang*. 2010. Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. Proc Natl Acad Sci USA. 107: 11250-4 IF=9.38
• Li, Jie, Zhao, Guo-Zhen, Huang, Hai-Yu, Zhu, Wen-Yong, Lee, Jae-Chan, Kim, Chang-Jin, Xu, Li-Hua, L Zhang, Li, Wen-Jun. 2010. Pseudonocardia rhizophila sp nov., a novel actinomycete isolated from a rhizosphere soil. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 98(1), 77-83
• Hu Y, Fu C, Yin Y, Cheng G, Lei F, Yang X, Li J, Ashforth EJ, Zhang L Zhang L, Zhu B. 2010. Construction and Preliminary Analysis of a Deep-Sea Sediment Metagenomic Fosmid Library from Qiongdongnan Basin, South China Sea. Mar Biotechnol (NY). 12 (6), 719-727
• Wang JF, Dai HQ, Wei YL, Zhu HJ, Yan YM, Wang YH, Long CL, Zhong HM, Zhang L, Cheng YX. 2010. Antituberculosis agents and an inhibitor of the para-aminobenzoic acid biosynthetic pathway from Hydnocarpus anthelminthica seeds. Chem Biodivers. 7(8):2046-53.
• Hengxing Liang, Huanqin Dai, Hai’an Fu, Xiaoping Dong, Abiodun Humphrey Adebayo, Lixin Zhang, Yongxian Cheng. 2010. Bioactive compounds from Rumex plants. Phytochemistry Letters. 3:181-184. IF=4.672
• Ashforth, E.J., Fu, C.Z., Liu, X.Y., Dai, H.Q., Song, F.H., Guo, H. and L.X. Zhang. 2010. Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep 27:1709-1719IF=8.88
• Yongfei Hu, Chengzhang Fu, Yunpeng Huang, Yeshi Yin, Gong Cheng, Fang Lei, Na Lu, Jing Li, Elizabeth Jane Ashforth, Lixin Zhang* and Baoli Zhu*. 2010. Novel lipolytic genes from microbial metagenomic library of South China Sea marine sediment. FEMS Microbiology Ecology. 72(2): 228-237 IF=3.335
• Jun Mao, Jian Wang, Huan-Qin Dai, Zhi-Dong Zhang, Qi-Yong Tang, Biao Ren, Na Yang, Michael Goodfellow, Li-Xin Zhang, Zhi-Heng Liu. 2010. A new genus of the suborder Pseudonocardineae, Yuhushiella Deserti gen. nov., sp. nov. Int J Syst Evol Microbiol. 61:621-30. Epub 2010 Apr 16.
• Jianlan You, Huanqin Dai, Zhihui Chen, Guangjie Liu, Zhengxiang He, Fuhang Song, Xiang Yang, Haian Fu, L Zhang*, Xiaoping Chen. 2010. Trichoderone, a Novel Cytotoxic Cyclopentenone and Cholesta-7, 22-diene-3β, 5α, 6β-triol with New Activities from the Marine-derived Fungus Trichoderma sp. J Ind Microbiol Biot 37 (3): 245-252 IF=1.912
• Hong Gao, Mei Liu, Xianlong Zhou, Jintao Liu, Ying Zhuo, Zhongxuan Gou, Bing Xu, Wenquan Zhang, Xiangyang Liu, Aiqun Luo, Chuansen Zheng, Xiaoping Chen, and L Zhang*.2010. Identification of avermectin-high-producing strains by high-throughput screening methods. Appl. Microbiol. Biotechnol. 85: 1219-1225 IF=2.896
• Liu Xiangyang, Ren Biao, Chen Ming, Wang Haibin, Kokare Chandrakant, Zhou Xianlong, Yu Zhenyan, Dai Huanqin, Song Fuhang, Liu Mei, Wang Jian, Wang Shujin, L Zhang*. 2010. Production and characterization of a bioemulsifier from marine Bacillus velezensis strain H3. Applied Microbiology and Biotechnology 87(5):1881-93.
• Gao H, Zhou X, Gou Z, Zhuo Y, Fu C, Liu M, Song F, Ashforth E, L Zhang*. 2010. Rational design for over-production of desirable microbial metabolites by precision engineering. Antonie van Leeuwenhoek. 98(2):151-63. Epub 2010 Apr 18.
• Wang W, Mao J, Zhang Z, Tang Q, Xie Y, Zhu J, Zhang L, Liu Z, Shi Y, Goodfellow M. Deinococcus wulumuqiensis sp. nov., and Deinococcus xibeiensis sp. nov., isolated from radiation-polluted soil. Int J Syst Evol Microbiol. 2010 Sep;60(Pt 9):2006-10.
• Florent E. Angly, Dana Willner, Alejandra Prieto-Davo, Robert A. Edwards, Robert Schmieder,Rebecca Vega-Thurber, Dionysios A. Antonopoulos5, Katie Barott, Matthew T. Cottrell, Christelle Desnues8, Elizabeth A. Dinsdale, Mike Furlan1, Matthew Haynes, Matthew R. Henn, Yongfei Hu, David L. Kirchman, Tracey McDole, John D. McPherson, Folker Meyer, R. Michael Miller, Egbert Mundt, Robert K. Naviaux, Beltran Rodriguez-Mueller, Rick Stevens, Linda Wegley, L Zhang, Baoli Zhu, Forest Rohwer. (2010). The GAAS Metagenomic Tool and Its Estimations of Viral and Microbial Average Genome Size in Four Major Biomes. PLOS Computational Biology. 5(12): e1000593. doi:10.1371/journal.pcbi.1000593
• Hong Gao, Ying Zhuo, Elizabeth Ashforth, and L Zhang*. Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites. Protein & Cell. 1(7): 621-626.
• Liu X, Tao X, Zou A, Yang S, L Zhang, and B Mu. 2010. Effect of the microbial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane. Protein & Cell. 1(7): 521-526.
• Zhao-Qi Song, Jing-Quan Chen, Hong-Chen Jiang, En-Min Zhou, Shu-Kun Tang, Xiao-Yang Zhi, L Zhang, Chuan-Lun L. Zhang, Wen-Jun Li. 2010. Diversity of Crenarchaeota in terrestrial hot springs in Tengchong, China. Extremophiles 14:287–296
• Liu X, Ashforth E, Ren B, Song F, Dai H, Liu M, Wang J, Xie Q, L Zhang*. 2010. Bioprospecting microbial natural product libraries from the marine environment for drug discovery. The Journal of Antibiotics (Tokyo). 63(8):415-22.
• Hong Gao, Mei Liu, Ying Zhuo, Xianlong Zhou, Jintao Liu, Wenquan Zhang, Zhongxuan Gou, Difei Chen, Peng Shang, Lixin Zhang*. 2010. Assessing the Potential of Induced Mutation Strategy for Avermectins-Overproducers. Applied and Environmental Microbiology. 76, 4583-4586 IF=3.801
• Fuhang Song, Huanqin Dai, Yaojun Tong, Biao Ren, Caixia Chen, Nuo Sun, Xiangyang Liu, Jiang Bian, Mei Liu, Hong Gao, Hongwei Liu, Xiaoping Chen, and L Zhang*. 2010. Trichodermaketones A-D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii. Journal of Natural Products. 73(5):806-810 IF=2.843
• Pei G, Dai H, Ren B, Liu X, Zhang L. Exploiting bioactive Enediynes from marine microbe based on activity and gene screening. Wei Sheng Wu Xue Bao. 2010 Apr 4;50(4):472-7.

2009

• Mei L, L. Zhang, Dai R. 2009. The inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats. J Enzyme Inhib Med Chem. 24(3): 753-762.ii IF=1.421
• Jones AL, Zhang L, Bai L, Seviour R. 15th International symposium on the biology of the Actinomycetes; Shanghai 2009. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 98(2), 117-118
• Jia XM, Z Ma, Y Jia, P Gao, J Zhang, Y Wang, Y Xu, L Wang, Y Cao, YB Cao, L. Zhang, YY Jiang. 2009. RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans. Cell Mol Life Sci. 66:122-134. IF=5.511
• Bian J, Li Y, Wang J, Song FH, Liu M, Dai HQ, Ren B, Gao H, Hu X, Liu ZH, Li WJ, Zhang LX* (2009). Amycolatopsis marina sp. nov., an actinomycete isolated from ocean sediment. Int J Syst Evol Microbiol, 59:477-481 IF=2.222
• Jian Wang, Yan Li, Jiang Bian, Shu-kun Tang, Biao Ren, Ming Chen, Wen-Jun Li, and L Zhang*. 2009. Prauserella marina sp. nov., isolated from ocean sediment of the South China Sea. Int J Syst Evol Microbiol. 60: 985-989 IF=2.222
• Huan-Qin Dai, Jian Wang, Yu-Hua Xin, Gang Pei, Shu-Kun Tang, Biao Ren, Alan Ward, Ji-Sheng Ruan, Wen-Jun Li, and L Zhang*. 2009. Verrucosispora sediminis sp. nov., a novel cyclodipeptide-producing actinomycete from the South China Sea. Int J Syst Evol Microbiol. doi:10.1099/ijs.0.017053-0. IF=2.222
• Gao H, M Liu, J Liu, H Dai, X Zhou, X Liu, Y Zhuo, W Zhang and L Zhang*. 2009. Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. Bioresource Technology. 100: 4012-4016 IF=4.453

2008

• Bian J, Song F, Zhang L. Strategies on the construction of high-quality microbial natural product library. Wei Sheng Wu Xue Bao. 2008 Aug;48(8):1132-7.
• Jia XM, Z Ma, Y Jia, P Gao, J Zhang, Y Wang, Y Xu, L Wang, Y Cao, YB Cao, L. Zhang, YY Jiang. 2008. RTA2, a novel gene involved in azole resistance in Candida albicans. Biochemical and Biophysical Research Communications 373: 631-6IF=2.548

2007

• Liang X., Zhang LX, Zhong J, and Huan L. 2007 Secretory expression of a heterologous nattokinase in Lactococcus lactis. Applied Microbiology and Biotechnology 75(1):95-101
• Wang Y, Wang YG, Chu J, Zhuang YP, L. Zhang*, Zhang SL. 2007. Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase. Applied Microbiology and Biotechnology 75(4):837-42
• You J, X Xue, L Cao, X Lu, J Wang, L. Zhang*, S Zhou. 2007. Vibrio Biofilm Inhibition by a Marine Actinomycete strain A66. Applied Microbiology and Biotechnology 76(5):1137-1144
• Zhang, L*., Yan K, Zhang Y, Bian J, Zheng C, Sun H, Chen Z, Sun N, Song Y, Zhuo Y, You J, et al. 2007. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc. Natl. Acad. Sci. USA. 104(11): 4606-11 IF=9.598

2006

• Zhang, L*., W Jia. 2006. Chinese Herbal Drug Industry: Past, Present and Future. (Biotechnology secondary metabolite by KG Ramawat and JM Merillon eds.), P417-443, ISBN: 978-1-57808-428-9, Science Publishers Inc, Enfield, USA.
• Xu Z, Zhang LX, Zhang JD, Cao YB, Yu YY, Jiang YY. 2006. cDNA microarray analysis of differential gene expression and regulation in clinically drug-resistant isolates of Candida albicans from bone marrow transplanted patients. International Journal of Medical Microbiology 296:421-34.

Before Joining IM, CAS

• Zhang, L., and A. Demain. (Editors-in-Chief) 2005. ” Natural Products: Drug Discovery, Therapeutic Medicine “, ISBN: 1-58829-383-1, Humana Press, USA
• Jia, W and L. Zhang*. 2005. Challenges and opportunities in the Chinese Herbal Drug Industry. (Ed: Zhang, L and A. Demain.), ” Natural Products: Drug Discovery, and Therapeutic Medicine “, ISBN: 1-58829-383-1, Humana Press, USA.
• Sun, N and L. Zhang*. 2005. siRNA in C. elegans. (Ed: Song E.), SiRNA Research: theory, applications and methods . Science publishing, China.
• Sun, N and L. Zhang*. 2005. siRNA in Drosophila. (Ed: Song E.), SiRNA Research: theory, applications and methods . Science publishing, China.
• Zhang, L*. 2005. Integrated approaches of discovering novel drugs from microbial natural products. (Ed: Zhang, L and A. Demain.), ” Natural Products: Drug Discovery and Therapeutic Medicine “, ISBN: 1-58829-383-1, Humana Press, USA. P33-56
• Zhang, L*. 2005. The Renaissances of Natural Products for Drug Discovery. (Ed: Zhang, L and A. Demain.), ” Natural Products: Drug Discovery and Therapeutic Medicine “, ISBN: 1-58829-383-1, Humana Press, USA.
• Jia, W and L. Zhang*. 2005. Challenges and opportunities in the Chinese Herbal Drug Industry. (Ed: Zhang, L and A. Demain.), ” Natural Products: Drug Discovery, and Therapeutic Medicine “, ISBN: 1-58829-383-1, Humana Press, USA.
• Zhang, L*., An, R.; Wang, J.; Sun, N.; Zhang, S.; Hu, J.; Kuai, J. 2005. Exploring novel bioactive compounds from marine microbes. Current Opinion In Microbiology, 8(3): 276-281 IF=7.654
• Zhang, L*., An R, J Wang, N Sun, S Zhang, J Hu, J Kuai. 2005. Isolation of novel bioactive compounds from marine microbes. Current Opinion In Microbiology, 8(3): 276-281
• Zhang, L. 2005. Coupling systems biology approach for synergistic drug discovery. Cell Research. 15(10): 92.
• Fujii K, Goldman EH, Park HR, L. Zhang, Chen J, Fu H. 2004. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene 23:5099-6104.
• FKnight V., JJ Sanglier, D DiTullio, S Bracilli, P Bonner, J Waters, D Hughes, L Zhang*. 2003. Diversifying microbial natural products for drug discovery. Applied Microbiology and Biotechnology 62: 446–458.
• Guo, J. et al. 2003. Tele-microscopic morphology observation of pathogens in shrimp. P205-206. In: Wang, S et al. (ed.), Studies on Terrestrial & Marine and Soil microorganism. ISBN: 7-5381-4123-5, Shenyang publishing, Shenyang, China.
• Zhang, L., J. Chen, and H. Fu. 2003. 14-3-3 structures and function. P63-70. In: Wang, S et al. (ed.), Studies on Terrestrial & Marine and Soil microorganism. ISBN: 7-5381-4123-5, Shenyang publishing, Shenyang, China.
• Pierceal, W., L. Zhang, and D. Hughes. 2003. Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery. ( ed: Haian Fu), ” Methods in Molecular Biology, vol 261: Protein-Protein Interactions”, Humana Press In., USA, 187-197.
• Chen, J., K. Fujii, L. Zhang, T.M.Roberts and H. Fu. 2001. Raf-1 promotes cell survival by antagonizing apoptosis signal regulating kinase 1 in a MEK-ERK independent mechanism. Proc. Natl. Acad. Sci. USA. 98(14): 7783-7788
• Masters, S., K. Pederson, L. Zhang, J. Barbieri, and H. Fu. 1999. Interaction of 14-3-3 with a Nonphosphorylated Protein Ligand, Exoenzyme S of Pseudomonas aeruginosa. Biochemistry. 38(16):5216-5221
• Zhang, L. J. Chen and H. Fu. 1999. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc. Natl. Acad. Sci. USA. 96 (15): 8511-8515.
• Wang, B., H. Yang, Y. Liu, T. Jelinek, L. Zhang, H. Fu, and E. Ruoslahti. 1999 Disrupting 14-3-3 interaction with Raf-1 and ADPRTs with a high affinity peptide antagonist. Biochemistry 38: 12499-12504.
• Zhang, L., H. Wang, B. Wang, J. Barbieri and H. Fu. 1999 Residues in the conserved amphipathic groove of 14-3-3 required for activation of Exoenzyme S of Pseudomonas aeruginosa. Biochemistry 38: 12159-12164.
• Zhang, L., H. Fu. 1998. Interaction of 14-3-3 proteins with ASK1 kinase that activates SAPK/JNK and p38 pathways. Proteins, 540
• Wang, H., L. Zhang, R. Liddington, and H. Fu. 1998. Mutations in the hydrophobic surface of an amphi- pathic groove of 14-3-3 disrupt its interaction with Raf-1 kinase. J.Biol.Chem. 273 : 16297-16304.
• Megidish, T., J. Cooper, L. Zhang, H. Fu, and S. Hakomori. 1998. A novel sphingosine-dependent protein kinase is associated with and specifically phosphorylates certain isoforms of 14-3-3 protein. J.Biol.Chem.. 273 (34): 21834-21845.
• Zhang, L., H. Wang, D. Liu, R. Liddington, and H. Fu. 1997. Raf-1 kinase and Exoenzyme S interact with 14-3-3 through a common site involving lysine-49. J.Biol.Chem. 272 (21): 13717-13724.
• Zhang, L. 1995. Conventional and genetic engineering to improve the yield of Rifamycin SV by A. mediteranei. Dissertation, Academia Sinica. Available: Microfilms in the Inst. of Applied Ecology, CAS
• Wu, W., C. Zhang, A. Lu, and L. Zhang. 1995. Isolation and properties of Rifamycin SV inactivation factor produced by A. mediteranei. Journal of Applied Ecology. 6 (3): 282-286.
• Zhang, L., C. Liu, J. Kuai, and P. Gao. 1994. Construction of a cDNA library of Sporocytophage B29 and Cloning of the CMCase gene. Journal of Applied Ecology. 5 (2): 156-158.
• Zhang, L., C. Zhang, A. Lu, and W. Wu. 1993. Rational screen model for high yield Rifamycin SV strains. P625-633. In: X.W. Zhang (ed.), Soil microbiology Research: theory, applications and methods . Shenyang publishing, Shenyang, China.
• Zhang, L., J. Wang, X. Guo, and J. Kuai. 1993. Studies on the extraction of PHB [ poly(b-hydroxybutyric acid )]from Sphaerotilus nataus. Journal of Microbiology 13 (1): 30-34.
• Wang, S., Z. Li, D. Xue, Q. Lu, and L. Zhang. 1992. The new fermentation technology of mutual adaptation in Vitamin C bilateral gene. Journal of Microbiology 12 (2): 80-82.